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Results: 591 patients were screened and 162 were randomized

Catecholaldehydes The catecholaldehydes DOPAL and DOPEGAL are MAO-generated metabolites of DA and NE, respectively

Delaflor-Weiss, E

reported significant reductions in inflammatory markers and oxidative stress among neonates with sepsis who received melatonin as adjunctive therapy, along with a decrease in mortality risk (El-Gendy et al., 2018)

Targeted validation in our study confirmed that genetic knockout of pmk-1 completely abrogated EULE-induced longevity and its associated benefits, establishing the pmk-1 /p38 MAPK pathway as the essential downstream effector axis that translates mitochondrial functional improvements into extended lifespan